Isotype-specific Ras.GTP-levels predict the efficacy of farnesyl transferase inhibitors against human astrocytomas regardless of Ras mutational status. [electronic resource]
Producer: 20010621Description: 4425-31 p. digitalISSN:- 0008-5472
- Alkyl and Aryl Transferases -- antagonists & inhibitors
- Animals
- Astrocytoma -- drug therapy
- Brain Neoplasms -- drug therapy
- Cell Division -- drug effects
- Enzyme Inhibitors -- pharmacology
- Farnesyltranstransferase
- Genes, ras -- genetics
- Glioblastoma -- drug therapy
- Guanosine Triphosphate -- metabolism
- Humans
- Immunohistochemistry
- Mice
- Mice, Inbred BALB C
- Mice, Inbred NOD
- Mice, Nude
- Mice, SCID
- Monomeric GTP-Binding Proteins -- metabolism
- Mutation
- Piperidines -- pharmacology
- Pyridines -- pharmacology
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
- ras Proteins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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