Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine. [electronic resource]
Producer: 20010607Description: 136-42 p. digitalISSN:- 0003-9861
- Amino Acid Sequence
- Amino Acid Substitution -- genetics
- Animals
- Arachidonate Lipoxygenases -- chemistry
- Base Sequence
- Blotting, Western
- Catalysis
- Chromatography, High Pressure Liquid
- Conserved Sequence -- genetics
- HeLa Cells
- Humans
- Hydroxyeicosatetraenoic Acids -- metabolism
- Iron -- metabolism
- Ligands
- Linoleic Acids -- metabolism
- Linoleic Acids, Conjugated
- Mice
- Mutagenesis, Site-Directed -- genetics
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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