Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity. [electronic resource]
Producer: 20010426Description: 2579-82 p. digitalISSN:- 0008-5472
- Antibiotics, Antineoplastic -- pharmacokinetics
- Antineoplastic Agents -- pharmacology
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- CDC2-CDC28 Kinases
- Caspase 3
- Caspases -- metabolism
- Cyclin A -- antagonists & inhibitors
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinases -- antagonists & inhibitors
- Cyclins -- biosynthesis
- Doxorubicin -- pharmacokinetics
- Drug Synergism
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Flavonoids -- pharmacology
- G2 Phase -- drug effects
- Humans
- Osteosarcoma -- drug therapy
- Piperidines -- pharmacology
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Retinoblastoma Protein -- deficiency
- S Phase -- drug effects
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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