An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. [electronic resource]
Producer: 20011204Description: 3375-80 p. digitalISSN:- 0027-8424
- Animals
- Aryl Hydrocarbon Hydroxylases
- Bile Acids and Salts -- metabolism
- Cell Line
- Cell Nucleus
- Chlorocebus aethiops
- Cholestasis -- metabolism
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- metabolism
- Enzyme Induction
- Humans
- Lithocholic Acid -- administration & dosage
- Mice
- Mice, Knockout
- Oxidoreductases, N-Demethylating -- metabolism
- Pregnane X Receptor
- Rats
- Receptors, Cytoplasmic and Nuclear -- physiology
- Receptors, Steroid -- physiology
- Substrate Specificity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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