Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. [electronic resource]
Producer: 20010329Description: 1493-9 p. digitalISSN:- 0008-5472
- Colonic Neoplasms -- enzymology
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinases -- antagonists & inhibitors
- Cyclins -- biosynthesis
- Enzyme Activation
- Fatty Acid Synthases -- antagonists & inhibitors
- G2 Phase -- drug effects
- Humans
- Malonyl Coenzyme A -- metabolism
- S Phase -- drug effects
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53 -- biosynthesis
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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