The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux. [electronic resource]
Producer: 20010222Description: 739-48 p. digitalISSN:- 0008-5472
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- ATP-Binding Cassette Transporters -- genetics
- Antineoplastic Agents -- pharmacology
- Biological Transport -- drug effects
- Camptothecin -- analogs & derivatives
- Cell Cycle -- drug effects
- Dose-Response Relationship, Drug
- Drug Interactions
- Drug Resistance, Neoplasm
- Drug Synergism
- Enzyme Inhibitors -- pharmacology
- ErbB Receptors -- drug effects
- Humans
- Irinotecan
- Morpholines -- pharmacology
- Neoplasm Proteins
- Neoplastic Stem Cells -- drug effects
- Phosphorylation -- drug effects
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Recombinant Fusion Proteins -- genetics
- Topoisomerase I Inhibitors
- Topotecan -- metabolism
- Transfection
- Tumor Cells, Cultured
- Tumor Stem Cell Assay
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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