The phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage activation and nitric oxide production in vitro and in vivo. [electronic resource]
Producer: 20010329Description: 272-9 p. digitalISSN:- 1521-6616
- 8-Bromo Cyclic Adenosine Monophosphate -- pharmacology
- Animals
- Autoimmune Diseases -- drug therapy
- Bucladesine -- pharmacology
- Cells, Cultured -- drug effects
- Colforsin -- pharmacology
- Cyclic AMP -- metabolism
- Diabetes Mellitus, Type 1 -- drug therapy
- Dibutyryl Cyclic GMP -- pharmacology
- Disease Models, Animal
- Drug Evaluation, Preclinical
- Enterotoxins -- pharmacology
- Enzyme Induction -- drug effects
- Female
- Interferon-gamma -- pharmacology
- Interleukin-12 -- pharmacology
- Lipopolysaccharides -- pharmacology
- Macrophage Activation -- drug effects
- Macrophages, Peritoneal -- drug effects
- Mice
- Mice, Inbred NOD
- Nitric Oxide -- biosynthesis
- Nitric Oxide Synthase -- biosynthesis
- Nitrites -- analysis
- Pentoxifylline -- pharmacology
- Phosphodiesterase Inhibitors -- pharmacology
- RNA, Messenger -- biosynthesis
- Recombinant Proteins -- pharmacology
- Reverse Transcriptase Polymerase Chain Reaction
- Rolipram -- pharmacology
- Tumor Necrosis Factor-alpha -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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