The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination. [electronic resource]
Producer: 20010202Description: 449-58 p. digitalISSN:- 0270-7306
- Amino Acid Motifs
- Binding Sites
- Catalysis
- DNA -- chemistry
- DNA Nucleotidyltransferases -- metabolism
- DNA-Binding Proteins -- metabolism
- Dimerization
- Gene Rearrangement -- genetics
- Homeodomain Proteins -- chemistry
- Humans
- Immunoglobulins -- genetics
- Mutation
- Nuclear Proteins
- Nucleic Acid Conformation
- Oligodeoxyribonucleotides -- chemistry
- Protein Structure, Tertiary
- Protein Subunits
- Receptors, Antigen, T-Cell -- genetics
- Recombinant Fusion Proteins
- Recombination, Genetic -- genetics
- VDJ Recombinases
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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