The physical association of protein kinase C theta with a lipid raft-associated inhibitor of kappa B factor kinase (IKK) complex plays a role in the activation of the NF-kappa B cascade by TCR and CD28. [electronic resource]
Producer: 20010125Description: 6933-40 p. digitalISSN:- 0022-1767
- CD28 Antigens -- genetics
- CD3 Complex -- physiology
- CD4-Positive T-Lymphocytes -- enzymology
- Cells, Cultured
- Enzyme Activation -- immunology
- Enzyme Inhibitors -- metabolism
- Gene Expression Regulation -- immunology
- Humans
- I-kappa B Kinase
- Isoenzymes -- biosynthesis
- Jurkat Cells -- enzymology
- Membrane Microdomains -- enzymology
- Membrane Proteins -- metabolism
- NF-kappa B -- metabolism
- Promoter Regions, Genetic -- immunology
- Protein Kinase C -- biosynthesis
- Protein Kinase C-theta
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Receptors, Antigen, T-Cell -- physiology
- Response Elements -- immunology
- Signal Transduction -- immunology
- Talin -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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