Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis. [electronic resource]
Producer: 20010103Description: 2859-67 p. digitalISSN:- 0964-6906
- Animals
- Apoptosis
- Caspase 1 -- genetics
- Caspases -- metabolism
- Cell Line
- Cell Nucleus -- metabolism
- Cytochrome c Group -- metabolism
- DNA Fragmentation
- Enzyme Activation
- Fluorescent Antibody Technique
- Gene Expression Regulation, Enzymologic
- Humans
- Huntingtin Protein
- Huntington Disease -- enzymology
- Mitochondria -- metabolism
- Nerve Tissue Proteins -- genetics
- Nuclear Proteins -- genetics
- Oxidative Stress
- PC12 Cells
- Peptides -- genetics
- RNA, Messenger -- genetics
- Rats
- Transfection
- Trinucleotide Repeat Expansion -- genetics
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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