Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP. [electronic resource]
Producer: 20001214Description: 43-53 p. digitalISSN:- 0022-2836
- Anti-HIV Agents -- metabolism
- Binding Sites
- Catalysis
- Crystallography, X-Ray
- Dideoxynucleotides
- Enzyme Stability
- Escherichia coli -- enzymology
- Humans
- Kinetics
- Models, Molecular
- Mutation -- genetics
- Nucleoside-Phosphate Kinase -- chemistry
- Nucleotides -- metabolism
- Phosphorylation
- Prodrugs -- metabolism
- Protein Binding
- Protein Conformation
- Recombinant Fusion Proteins -- chemistry
- Thymine Nucleotides -- metabolism
- Zidovudine -- analogs & derivatives
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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