Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers. [electronic resource]
Producer: 20001213Description: 291-9 p. digitalISSN:- 1061-4036
- Adenocarcinoma -- genetics
- Animals
- Breast Neoplasms -- genetics
- COS Cells
- Carrier Proteins -- genetics
- Cell Cycle Proteins -- genetics
- Cell Transformation, Neoplastic -- genetics
- Cells, Cultured
- Cellular Senescence -- genetics
- Chromosomes, Human, Pair 17 -- genetics
- Cyclin-Dependent Kinase Inhibitor p16
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor
- Female
- Fibroblasts -- cytology
- Gene Amplification
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Genes, BRCA1
- Humans
- Mice
- Neoplasm Proteins -- biosynthesis
- Neoplastic Syndromes, Hereditary -- genetics
- Nuclear Proteins -- genetics
- Oncogenes
- Polycomb Repressive Complex 1
- Promoter Regions, Genetic
- Protein Biosynthesis
- Proteins -- genetics
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins c-myc -- antagonists & inhibitors
- Proto-Oncogene Proteins p21(ras) -- antagonists & inhibitors
- Repressor Proteins -- genetics
- Retinoblastoma-Binding Protein 1
- T-Box Domain Proteins -- genetics
- Transcription Factor DP1
- Transcription Factors -- antagonists & inhibitors
- Transfection
- Tumor Cells, Cultured
- Tumor Suppressor Protein p14ARF
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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