Functional defects of NK cells treated with chloroquine mimic the lytic defects observed in perforin-deficient mice. [electronic resource]
Producer: 20001130Description: 5048-53 p. digitalISSN:- 0022-1767
- Animals
- Bone Marrow Cells -- drug effects
- Bone Marrow Transplantation -- immunology
- Cell Movement -- drug effects
- Cells, Cultured
- Chloroquine -- pharmacology
- Cytotoxicity, Immunologic -- drug effects
- Fas Ligand Protein
- Graft Rejection -- genetics
- Histocompatibility Antigens Class I -- genetics
- Humans
- Immunosuppressive Agents -- pharmacology
- Injections, Intravenous
- Jurkat Cells
- Killer Cells, Natural -- drug effects
- Ligands
- Lung Neoplasms -- immunology
- Membrane Glycoproteins -- antagonists & inhibitors
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Mice, Knockout
- Perforin
- Pore Forming Cytotoxic Proteins
- Protein Processing, Post-Translational -- drug effects
- Tumor Cells, Cultured -- drug effects
- fas Receptor -- metabolism
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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