Molecular architecture of the mutagenic active site of human immunodeficiency virus type 1 reverse transcriptase: roles of the beta 8-alpha E loop in fidelity, processivity, and substrate interactions. [electronic resource]
Producer: 20000928Description: 10684-94 p. digitalISSN:- 0006-2960
- Amino Acid Substitution -- genetics
- Anti-HIV Agents -- pharmacology
- Base Pair Mismatch
- Binding Sites -- genetics
- DNA Mutational Analysis
- DNA Primers -- chemistry
- Dideoxynucleotides
- Glutamine -- genetics
- Glycine -- genetics
- HIV Reverse Transcriptase -- antagonists & inhibitors
- Humans
- Lac Operon
- Lysine -- genetics
- Mutagenesis, Site-Directed
- Protein Processing, Post-Translational -- genetics
- Protein Structure, Secondary -- genetics
- RNA -- chemistry
- Substrate Specificity -- genetics
- Templates, Genetic
- Thymine Nucleotides -- pharmacology
- Tryptophan -- genetics
- Zidovudine -- analogs & derivatives
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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