A ribozyme derived from the catalytic subunit of RNase P from Escherichia coli is highly effective in inhibiting replication of herpes simplex virus 1. [electronic resource]
Producer: 20000921Description: 817-26 p. digitalISSN:- 0022-2836
- Animals
- Antiviral Agents -- chemistry
- Base Sequence
- Catalytic Domain
- Cell Line
- Endoribonucleases -- chemistry
- Escherichia coli -- enzymology
- Escherichia coli Proteins
- Gene Expression Regulation, Viral
- Gene Silencing
- Genes, Viral -- genetics
- Herpesvirus 1, Human -- growth & development
- Humans
- Immediate-Early Proteins -- antagonists & inhibitors
- RNA, Catalytic -- chemistry
- RNA, Messenger -- genetics
- RNA, Viral -- genetics
- Ribonuclease P
- Substrate Specificity
- Transcription Factors -- antagonists & inhibitors
- Transfection
- Virus Replication
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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