Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. [electronic resource]
Producer: 20000905Description: 2797-804 p. digitalISSN:- 0022-2623
- Antineoplastic Agents -- chemical synthesis
- CDC2 Protein Kinase -- antagonists & inhibitors
- CDC2-CDC28 Kinases
- Crystallography, X-Ray
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinases -- antagonists & inhibitors
- Drug Screening Assays, Antitumor
- Enzyme Inhibitors -- chemical synthesis
- Humans
- Hydrogen Bonding
- Models, Molecular
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Purines -- chemical synthesis
- Pyrimidines -- chemical synthesis
- Structure-Activity Relationship
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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