CYP3A4 is mainly responsibile for the metabolism of a new vinca alkaloid, vinorelbine, in human liver microsomes. [electronic resource]
Producer: 20001004Description: 1121-7 p. digitalISSN:- 0090-9556
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- drug effects
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- pharmacology
- Humans
- Hydroxylation -- drug effects
- Isoenzymes -- genetics
- Kinetics
- Microsomes, Liver -- drug effects
- Mixed Function Oxygenases -- drug effects
- Recombinant Proteins -- metabolism
- Steroid Hydroxylases -- drug effects
- Substrate Specificity
- Testosterone -- metabolism
- Vinblastine -- analogs & derivatives
- Vinca Alkaloids -- pharmacokinetics
- Vinorelbine
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Publication Type: Journal Article
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