Malignant transformation of human fibroblast cell strain MSU-1.1 by N-methyl-N-nitrosourea: evidence of elimination of p53 by homologous recombination. [electronic resource]
Producer: 20000831Description: 4105-11 p. digitalISSN:- 0008-5472
- Alleles
- Carcinogens -- toxicity
- Cell Line
- Cell Transformation, Neoplastic -- drug effects
- Codon -- genetics
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- pharmacology
- Fibroblasts -- drug effects
- Gene Deletion
- Genes, p53 -- genetics
- Guanine -- analogs & derivatives
- Homozygote
- Humans
- Loss of Heterozygosity
- Methylnitrosourea -- toxicity
- O(6)-Methylguanine-DNA Methyltransferase -- antagonists & inhibitors
- Recombination, Genetic -- drug effects
- Transcriptional Activation -- drug effects
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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