E1A overcomes the apoptosis block in BCR-ABL+ leukemia cells and renders cells susceptible to induction of apoptosis by chemotherapeutic agents. [electronic resource]
Producer: 20000824Description: 3957-64 p. digitalISSN:- 0008-5472
- Adenovirus E1A Proteins -- metabolism
- Antibiotics, Antineoplastic -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- CDC2 Protein Kinase -- metabolism
- Caspase 3
- Caspases -- metabolism
- Cell Cycle -- drug effects
- Cell Division
- DNA Damage -- drug effects
- Daunorubicin -- pharmacology
- Dose-Response Relationship, Drug
- Etoposide -- pharmacology
- Flow Cytometry
- Fusion Proteins, bcr-abl -- metabolism
- Humans
- K562 Cells
- Leukemia -- enzymology
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- enzymology
- Luciferases -- metabolism
- Microscopy, Phase-Contrast
- Nucleic Acid Synthesis Inhibitors -- pharmacology
- Peptides -- pharmacology
- Plasmids
- Poly(ADP-ribose) Polymerases -- metabolism
- Transfection
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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