Chloroquine interferes with lipopolysaccharide-induced TNF-alpha gene expression by a nonlysosomotropic mechanism. [electronic resource]
Producer: 20000822Description: 1534-40 p. digitalISSN:- 0022-1767
- Anti-Bacterial Agents -- pharmacology
- Biological Transport -- drug effects
- Cell Nucleus -- drug effects
- Chemokine CCL5 -- metabolism
- Chloroquine -- pharmacology
- DNA-Binding Proteins -- metabolism
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Immunologic
- Gene Expression Regulation -- drug effects
- Humans
- Hydrogen-Ion Concentration
- Immunosuppressive Agents -- pharmacology
- Interleukin-1 -- antagonists & inhibitors
- Interleukin-6 -- antagonists & inhibitors
- Leukocytes, Mononuclear -- drug effects
- Lipopolysaccharides -- antagonists & inhibitors
- Lysosomes -- drug effects
- Macrolides
- NF-kappa B -- metabolism
- NF-kappa B p50 Subunit
- Protein Biosynthesis -- drug effects
- Protein Processing, Post-Translational -- drug effects
- RNA, Messenger -- antagonists & inhibitors
- Transcription Factor RelA
- Transcription, Genetic -- drug effects
- Tumor Necrosis Factor-alpha -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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