The type IV phosphodiesterase specific inhibitor mesopram inhibits experimental autoimmune encephalomyelitis in rodents. [electronic resource]
Producer: 20000825Description: 136-46 p. digitalISSN:- 0165-5728
- 3',5'-Cyclic-AMP Phosphodiesterases -- antagonists & inhibitors
- Acute Disease
- Animals
- Anti-Inflammatory Agents -- pharmacology
- Cell Division -- drug effects
- Cells, Cultured
- Central Nervous System -- drug effects
- Chronic Disease
- Cyclic Nucleotide Phosphodiesterases, Type 4
- Dose-Response Relationship, Drug
- Down-Regulation -- drug effects
- Encephalomyelitis, Autoimmune, Experimental -- drug therapy
- Enzyme Inhibitors -- pharmacology
- Female
- Humans
- Inflammation -- drug therapy
- Interferon-gamma -- biosynthesis
- Interleukin-5 -- biosynthesis
- Lymphocyte Activation -- drug effects
- Mice
- Mice, Inbred Strains
- Multiple Sclerosis -- drug therapy
- Oxazoles -- pharmacology
- Rats
- Rats, Inbred Lew
- Recurrence
- Spleen -- drug effects
- Substrate Specificity
- Th1 Cells -- cytology
- Th2 Cells -- cytology
- Tumor Necrosis Factor-alpha -- metabolism
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Publication Type: Journal Article
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