Homocamptothecin, an E-ring-modified camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon cancers obtained from surgery and maintained in vitro under histotypical culture conditions. [electronic resource]
Producer: 20000803Description: 1557-62 p. digitalISSN:- 1078-0432
- Antineoplastic Agents -- pharmacology
- Biopsy
- Camptothecin -- analogs & derivatives
- Cell Division -- drug effects
- Colon -- drug effects
- Colonic Neoplasms -- drug therapy
- Culture Techniques
- DNA Topoisomerases, Type I -- metabolism
- Dose-Response Relationship, Drug
- Doxorubicin -- pharmacology
- Enzyme Inhibitors -- pharmacology
- Etoposide -- pharmacology
- Humans
- Irinotecan
- Thymidine -- metabolism
- Topoisomerase I Inhibitors
- Topotecan -- pharmacology
- Tritium
- Tumor Cells, Cultured
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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