Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity. [electronic resource]
Producer: 20000621Description: 585-91 p. digitalISSN:- 0022-3565
- Aryl Hydrocarbon Hydroxylases
- Benzoflavones -- metabolism
- Binding Sites
- Cloning, Molecular
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- chemistry
- Humans
- Hydroxylation
- Kinetics
- Mixed Function Oxygenases -- chemistry
- Models, Molecular
- Mutation -- genetics
- Oxidation-Reduction
- Phenylalanine -- chemistry
- Progesterone -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Steroid Hydroxylases -- metabolism
- Substrate Specificity
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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