Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes. [electronic resource]
Producer: 20000602Description: 273-84 p. digitalISSN:- 0049-8254
- Animals
- Aryl Hydrocarbon Hydroxylases
- Blotting, Western
- Cells, Cultured
- Chromans -- pharmacology
- Cytochrome P-450 CYP1A1 -- metabolism
- Cytochrome P-450 CYP1A2 -- metabolism
- Cytochrome P-450 CYP2B6
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- metabolism
- Dexamethasone -- pharmacology
- Dose-Response Relationship, Drug
- Drug Interactions
- Enzyme Activation
- Enzyme Inhibitors -- pharmacology
- Glucocorticoids -- pharmacology
- Humans
- Hypoglycemic Agents -- pharmacology
- Liver -- drug effects
- Male
- Microsomes, Liver -- metabolism
- Mixed Function Oxygenases -- metabolism
- Oxidoreductases, N-Demethylating -- metabolism
- RNA, Messenger -- metabolism
- Rats
- Rats, Wistar
- Reverse Transcriptase Polymerase Chain Reaction
- Rifampin -- pharmacology
- Steroid Hydroxylases -- metabolism
- Substrate Specificity
- Thiazoles -- pharmacology
- Thiazolidinediones
- Troglitazone
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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