Both normal and transforming PCPH proteins have guanosine diphosphatase activity but only the oncoprotein cooperates with Ras in activating extracellular signal-regulated kinase ERK1. [electronic resource]
Producer: 20000504Description: 1720-8 p. digitalISSN:- 0008-5472
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Base Sequence
- COS Cells
- Cell Extracts -- chemistry
- Cell Line
- Cricetinae
- Escherichia coli -- enzymology
- Gene Expression Regulation
- Genetic Complementation Test
- Guanosine Diphosphate -- metabolism
- Guanosine Triphosphate -- metabolism
- Humans
- Mesocricetus
- Mice
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinases -- metabolism
- Molecular Sequence Data
- Oncogene Proteins -- genetics
- Protein Biosynthesis
- Pyrophosphatases -- metabolism
- Recombinant Fusion Proteins -- genetics
- Saccharomyces cerevisiae -- genetics
- Sequence Homology, Amino Acid
- Transcription, Genetic
- Transfection
- Tumor Cells, Cultured
- ras Proteins -- metabolism
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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