Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription. [electronic resource]
Producer: 20000608Description: 514-20 p. digitalISSN:- 0022-2275
- Animals
- Anticholesteremic Agents -- pharmacology
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Binding Sites
- Cholesterol 7-alpha-Hydroxylase -- biosynthesis
- Clofibric Acid -- pharmacology
- DNA-Binding Proteins
- Gene Expression Regulation, Enzymologic
- Genes, Reporter
- Hepatocyte Nuclear Factor 4
- Humans
- Liver -- metabolism
- Models, Genetic
- Peroxisome Proliferators -- pharmacology
- Phosphoproteins -- metabolism
- Promoter Regions, Genetic
- Protein Binding
- Pyrimidines -- pharmacology
- Rats
- Receptors, Cytoplasmic and Nuclear -- agonists
- Receptors, Retinoic Acid -- metabolism
- Regulatory Sequences, Nucleic Acid
- Response Elements
- Retinoid X Receptors
- Species Specificity
- Transcription Factors -- agonists
- Transcription, Genetic
- Transcriptional Activation
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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