Effects of cigarette smoke on immune response: chronic exposure to cigarette smoke impairs antigen-mediated signaling in T cells and depletes IP3-sensitive Ca(2+) stores. [electronic resource]
Producer: 20000421Description: 166-71 p. digitalISSN:- 0022-3565
- Animals
- Antibody-Producing Cells -- drug effects
- Antigens -- immunology
- Calcium -- metabolism
- Cotinine -- blood
- Enzyme Activation -- drug effects
- Female
- Health Status
- Immunity -- drug effects
- Inositol 1,4,5-Trisphosphate -- physiology
- Isoenzymes -- metabolism
- Nicotine -- pharmacology
- Nicotinic Agonists -- pharmacology
- Phospholipase C gamma
- Plants, Toxic
- Protein-Tyrosine Kinases -- metabolism
- Rats
- Rats, Inbred F344
- Receptor-CD3 Complex, Antigen, T-Cell -- drug effects
- Signal Transduction -- drug effects
- Smoke -- adverse effects
- Spleen -- cytology
- T-Lymphocytes -- drug effects
- Nicotiana
- Type C Phospholipases -- metabolism
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Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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