NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity. [electronic resource]
Producer: 20000330Description: 5416-24 p. digitalISSN:- 0021-9258
- Antibiotics, Antineoplastic -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- Breast Neoplasms -- drug therapy
- Cell Division -- drug effects
- Cytochrome Reductases -- metabolism
- Cytochrome-B(5) Reductase
- Dicumarol -- pharmacology
- Dose-Response Relationship, Drug
- Drug Synergism
- Enzyme Inhibitors -- pharmacology
- Flow Cytometry
- Humans
- Models, Biological
- NAD -- metabolism
- NADH, NADPH Oxidoreductases -- metabolism
- NADPH-Ferrihemoprotein Reductase
- Naphthoquinones -- pharmacology
- Proteins -- metabolism
- Quinone Reductases -- metabolism
- Transfection
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53 -- metabolism
- Vitamin K -- pharmacology
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Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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