Role of the amino acid 45 residue in reduced folate carrier function and ion-dependent transport as characterized by site-directed mutagenesis. [electronic resource]
Producer: 20000302Description: 317-23 p. digitalISSN:- 0026-895X
- Amino Acid Substitution
- Animals
- Anions -- metabolism
- Antimetabolites, Antineoplastic -- pharmacology
- Biological Transport
- Carrier Proteins -- genetics
- Folic Acid -- metabolism
- Glutamic Acid -- metabolism
- Leucovorin -- metabolism
- Leukemia L1210
- Membrane Proteins
- Membrane Transport Proteins
- Methotrexate -- pharmacology
- Mice
- Mutagenesis, Site-Directed
- Reduced Folate Carrier Protein
- Tetrahydrofolates -- metabolism
- Transfection
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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