Stability of cytotoxic luteinizing hormone-releasing hormone conjugate (AN-152) containing doxorubicin 14-O-hemiglutarate in mouse and human serum in vitro: implications for the design of preclinical studies. [electronic resource]
Producer: 20000302Description: 829-34 p. digitalISSN:- 0027-8424
- Adult
- Animals
- Antineoplastic Agents -- blood
- Bombesin -- chemistry
- Carboxylesterase
- Carboxylic Ester Hydrolases -- antagonists & inhibitors
- Cholinesterase Inhibitors -- pharmacology
- Dose-Response Relationship, Drug
- Doxorubicin -- analogs & derivatives
- Drug Evaluation, Preclinical
- Drug Interactions
- Drug Stability
- Gonadotropin-Releasing Hormone -- analogs & derivatives
- Half-Life
- Humans
- Hydrolysis
- Isoflurophate -- pharmacology
- Male
- Mice
- Mice, Nude
- Nitrophenols -- pharmacology
- Paraoxon -- pharmacology
- Pyrroles -- pharmacology
- Weight Loss -- drug effects
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Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
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