Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels. [electronic resource]
Producer: 20000218Description: 1201-8 p. digitalISSN:- 0021-9258
- Amino Acid Sequence
- Animals
- Bacterial Proteins -- chemistry
- Binding Sites
- Calcium Channels -- chemistry
- Cell Line
- Charybdotoxin -- chemistry
- Drug Design
- Humans
- Intermediate-Conductance Calcium-Activated Potassium Channels
- Kv1.3 Potassium Channel
- Models, Molecular
- Molecular Sequence Data
- Potassium Channels -- chemistry
- Potassium Channels, Voltage-Gated
- Protein Conformation
- Protein Structure, Secondary
- Rats
- Recombinant Proteins -- chemistry
- Sequence Alignment
- T-Lymphocytes -- physiology
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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