Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. [electronic resource]
Producer: 20000127Description: 879-92 p. digitalISSN:- 0896-6273
- Animals
- Ataxin-1
- Ataxins
- Cell Nucleus -- genetics
- Cells, Cultured
- Cysteine Endopeptidases -- metabolism
- Fluorescent Antibody Technique
- HeLa Cells
- Humans
- Immunoblotting
- Immunohistochemistry
- Inclusion Bodies -- genetics
- Ligases -- deficiency
- Mice
- Mice, Knockout
- Microscopy, Confocal
- Multienzyme Complexes -- metabolism
- Mutation -- physiology
- Nerve Tissue Proteins -- biosynthesis
- Nuclear Proteins -- biosynthesis
- Peptides -- toxicity
- Phenotype
- Plasmids -- genetics
- Proteasome Endopeptidase Complex
- Purkinje Cells -- metabolism
- Spinocerebellar Degenerations -- genetics
- Ubiquitin-Protein Ligases
- Ubiquitins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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