Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination. [electronic resource]
Producer: 20000111Description: 3059-69 p. digitalISSN:- 0890-9369
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Binding Sites
- CHO Cells
- Catalysis
- Catalytic Domain
- Cricetinae
- Cricetulus
- Cysteine -- chemistry
- DNA -- genetics
- DNA Nucleotidyltransferases -- metabolism
- DNA-Binding Proteins
- Gene Rearrangement -- physiology
- Homeodomain Proteins -- chemistry
- Humans
- Lymphocytes -- metabolism
- Manganese -- physiology
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Nuclear Proteins
- Recombinant Fusion Proteins -- physiology
- Sequence Alignment
- Sequence Homology, Amino Acid
- Structure-Activity Relationship
- Transfection
- VDJ Recombinases
- Vertebrates -- genetics
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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