Activation of a cAMP pathway and induction of melanogenesis correlate with association of p16(INK4) and p27(KIP1) to CDKs, loss of E2F-binding activity, and premature senescence of human melanocytes. [electronic resource]
Producer: 20000111Description: 561-72 p. digitalISSN:- 0014-4827
- Carrier Proteins
- Cell Cycle Proteins
- Cells, Cultured
- Cellular Senescence -- physiology
- Cyclic AMP -- physiology
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase Inhibitor p16 -- genetics
- Cyclin-Dependent Kinase Inhibitor p27
- Cyclin-Dependent Kinases -- metabolism
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor
- E2F2 Transcription Factor
- E2F4 Transcription Factor
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Humans
- Melanins -- biosynthesis
- Melanocytes -- cytology
- Melanoma -- enzymology
- Microphthalmos -- genetics
- Microtubule-Associated Proteins -- genetics
- Phosphorylation
- Proto-Oncogene Proteins
- Retinoblastoma Protein -- metabolism
- Retinoblastoma-Binding Protein 1
- S Phase -- physiology
- Signal Transduction -- physiology
- Skin Neoplasms -- enzymology
- Transcription Factor DP1
- Transcription Factors -- genetics
- Tumor Suppressor Proteins
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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