Platelet-derived growth factor-BB inhibits rat alpha1D-adrenergic receptor gene expression in vascular smooth muscle cells by inducing AP-2-like protein binding to alpha1D proximal promoter region. [electronic resource]
Producer: 19991217Description: 1152-61 p. digitalISSN:- 0026-895X
- Animals
- Becaplermin
- Cloning, Organism
- DNA-Binding Proteins -- metabolism
- Gene Expression Regulation -- drug effects
- In Vitro Techniques
- Male
- Molecular Sequence Data
- Muscle, Smooth, Vascular -- drug effects
- Platelet-Derived Growth Factor -- pharmacology
- Promoter Regions, Genetic
- Protein Binding -- drug effects
- Proto-Oncogene Proteins c-sis
- RNA, Messenger -- biosynthesis
- Rats
- Rats, Sprague-Dawley
- Receptors, Adrenergic, alpha-1 -- drug effects
- Sp1 Transcription Factor -- metabolism
- Transcription Factor AP-2
- Transcription Factors -- metabolism
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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