Inhibition of dihydrofolate reductases from Toxoplasma gondii, Pneumocystis carinii, and rat liver by rotationally restricted analogues of pyrimethamine and metoprine. [electronic resource]
Producer: 19991028Description: 25-40 p. digitalISSN:- 1055-9612
- Animals
- Binding Sites
- Computer Simulation
- Folic Acid -- analogs & derivatives
- Folic Acid Antagonists -- pharmacology
- Liver -- drug effects
- Molecular Structure
- Oxidoreductases -- antagonists & inhibitors
- Pneumocystis -- drug effects
- Pyrimethamine -- analogs & derivatives
- Rats
- Serine -- chemistry
- Threonine -- chemistry
- Toxoplasma -- drug effects
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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