Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT. [electronic resource]
Producer: 19990813Description: 4394-400 p. digitalISSN:- 0950-9232
- Adenosine Triphosphatases
- Animals
- Carcinogens
- DNA Repair Enzymes
- DNA-Binding Proteins
- Genetic Predisposition to Disease
- Humans
- Hypersensitivity
- Lymphoma -- metabolism
- Methylnitrosourea
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Mismatch Repair Endonuclease PMS2
- Models, Biological
- O(6)-Methylguanine-DNA Methyltransferase -- metabolism
- Polymerase Chain Reaction
- Proteins -- genetics
- Thymus Neoplasms -- chemically induced
- Time Factors
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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