Tissue plasminogen activator binds to human vascular smooth muscle cells by a novel mechanism. Evidence for a reciprocal linkage between inhibition of catalytic activity and cellular binding. [electronic resource]
Producer: 19990819Description: 21555-61 p. digitalISSN:- 0021-9258
- Amino Acid Chloromethyl Ketones -- pharmacology
- Binding Sites
- Binding, Competitive
- Catalysis
- Cells, Cultured
- Circular Dichroism
- Fibrin -- metabolism
- Humans
- Kinetics
- Muscle, Smooth, Vascular -- metabolism
- Mutagenesis, Site-Directed
- Protein Conformation
- Recombinant Proteins -- chemistry
- Saphenous Vein -- metabolism
- Serine Proteinase Inhibitors -- pharmacology
- Tissue Plasminogen Activator -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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