Methyltransferase inhibitor S-adenosyl-L-homocysteine sensitizes human breast carcinoma MCF7 cells and related TNF-resistant derivatives to TNF-mediated cytotoxicity via the ceramide-independent pathway. [electronic resource]
Producer: 19990902Description: 247-52 p. digitalISSN:- 1148-5493
- Adenocarcinoma -- pathology
- Amino Acid Chloromethyl Ketones -- pharmacology
- Apoptosis -- drug effects
- Arabidopsis Proteins
- Breast Neoplasms -- pathology
- Caspase Inhibitors
- Ceramides -- physiology
- Cysteine Proteinase Inhibitors -- pharmacology
- DNA (Cytosine-5-)-Methyltransferases -- antagonists & inhibitors
- DNA Methylation -- drug effects
- Drug Resistance
- Fatty Acid Desaturases -- genetics
- Female
- Humans
- Recombinant Fusion Proteins -- pharmacology
- S-Adenosylhomocysteine -- pharmacology
- Tumor Necrosis Factor-alpha -- toxicity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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