Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines. [electronic resource]
Producer: 19990728Description: 3077-83 p. digitalISSN:- 0008-5472
- Apoptosis -- drug effects
- Caspase 3
- Caspases -- metabolism
- Cisplatin -- toxicity
- Cytochrome c Group -- metabolism
- Cytoplasm -- metabolism
- Drug Resistance, Neoplasm
- Enzyme Activation
- Female
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Kinetics
- Mitochondria -- metabolism
- Ovarian Neoplasms
- Proto-Oncogene Proteins -- analysis
- Proto-Oncogene Proteins c-bcl-2 -- analysis
- Signal Transduction
- Substrate Specificity
- Tumor Cells, Cultured
- bcl-2-Associated X Protein
- bcl-X Protein
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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