In-vivo and in-vitro metabolic clearance of midazolam, a cytochrome P450 3A substrate, by the liver under normal and increased enzyme activity in rats. [electronic resource]
Producer: 19990803Description: 405-10 p. digitalISSN:- 0022-3573
- Administration, Oral
- Animals
- Anti-Anxiety Agents -- pharmacokinetics
- Aryl Hydrocarbon Hydroxylases
- Clotrimazole -- pharmacology
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- metabolism
- Dexamethasone -- pharmacology
- Enzyme Activation -- drug effects
- In Vitro Techniques
- Intestinal Mucosa -- metabolism
- Liver -- enzymology
- Male
- Metabolic Clearance Rate
- Microsomes, Liver -- metabolism
- Midazolam -- metabolism
- Oxidoreductases, N-Demethylating -- metabolism
- Rats
- Rats, Sprague-Dawley
- Substrate Specificity
- Time Factors
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Publication Type: Journal Article
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