CD94/NKG2-A inhibitory complex blocks CD16-triggered Syk and extracellular regulated kinase activation, leading to cytotoxic function of human NK cells. [electronic resource]
Producer: 19990630Description: 7181-8 p. digitalISSN:- 0022-1767
- Animals
- Antigens, CD -- immunology
- Calcium-Calmodulin-Dependent Protein Kinases -- antagonists & inhibitors
- Clone Cells
- Cytotoxicity, Immunologic -- immunology
- Enzyme Activation -- immunology
- Enzyme Precursors -- antagonists & inhibitors
- Humans
- Intracellular Signaling Peptides and Proteins
- Killer Cells, Natural -- enzymology
- Lectins, C-Type
- Macromolecular Substances
- Mast-Cell Sarcoma
- Membrane Glycoproteins -- immunology
- Mice
- NK Cell Lectin-Like Receptor Subfamily D
- Phosphorylation
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Receptors, IgG -- antagonists & inhibitors
- Syk Kinase
- Tumor Cells, Cultured
- Tyrosine -- antagonists & inhibitors
- ras Proteins -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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