DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts. [electronic resource]
Producer: 19990622Description: 1021-30 p. digitalISSN:- 1043-0342
- Animals
- Antineoplastic Agents, Alkylating -- pharmacology
- Bone Marrow Transplantation
- Carmustine -- pharmacology
- Cell Division -- drug effects
- Colonic Neoplasms -- drug therapy
- Combined Modality Therapy
- Drug Resistance, Neoplasm
- Genetic Vectors
- Guanine -- analogs & derivatives
- Humans
- Mice
- Mice, Nude
- Neoplasm Transplantation
- O(6)-Methylguanine-DNA Methyltransferase -- genetics
- Retroviridae -- genetics
- Transduction, Genetic
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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