A single point mutation in the pore region of the epithelial Na+ channel changes ion selectivity by modifying molecular sieving. [electronic resource]
Producer: 19990512Description: 4170-5 p. digitalISSN:- 0027-8424
- Amino Acid Sequence
- Animals
- Cations, Divalent -- metabolism
- Cations, Monovalent -- metabolism
- Conserved Sequence
- Epithelial Sodium Channels
- Female
- Macromolecular Substances
- Membrane Potentials -- drug effects
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Oocytes -- drug effects
- Point Mutation
- Protein Conformation
- Rats
- Recombinant Proteins -- drug effects
- Sequence Alignment
- Sequence Homology, Amino Acid
- Serine
- Sodium Channels -- chemistry
- Xenopus laevis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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