Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex. [electronic resource]
Producer: 19990317Description: 189-99 p. digitalISSN:- 0014-4827
- CDC2-CDC28 Kinases
- Carrier Proteins
- Cell Cycle -- drug effects
- Cell Cycle Proteins
- Cyclin A -- chemistry
- Cyclin E -- metabolism
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinases -- antagonists & inhibitors
- DNA -- antagonists & inhibitors
- DNA Fragmentation -- drug effects
- DNA, Neoplasm -- metabolism
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Growth Inhibitors -- pharmacology
- Humans
- Macromolecular Substances
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Quinazolines -- pharmacology
- Retinoblastoma-Binding Protein 1
- Thiophenes -- pharmacology
- Thymidine -- physiology
- Thymidylate Synthase -- antagonists & inhibitors
- Transcription Factor DP1
- Transcription Factors -- biosynthesis
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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