Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). (Record no. 28735940)

MARC details
000 -LEADER
fixed length control field 02606 a2200745 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250517232958.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 201910s 0 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1520-4804
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.1021/acs.jmedchem.8b00917
Source of number or code doi
040 ## - CATALOGING SOURCE
Original cataloging agency NLM
Language of cataloging eng
Transcribing agency NLM
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Fensome, Andrew
264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Date of production, publication, distribution, manufacture, or copyright notice 20191007
245 00 - TITLE STATEMENT
Title Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).
Medium [electronic resource]
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Journal of medicinal chemistry
Date of publication, distribution, etc. 10 2018
300 ## - PHYSICAL DESCRIPTION
Extent 8597-8612 p.
Other physical details digital
500 ## - GENERAL NOTE
General note Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Animals
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Antitubercular Agents
General subdivision pharmacology
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Arthritis, Experimental
General subdivision chemically induced
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Female
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Janus Kinase 1
General subdivision antagonists & inhibitors
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Molecular Structure
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Mycobacterium tuberculosis
General subdivision drug effects
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Protein Kinase Inhibitors
General subdivision pharmacology
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Pyrazoles
General subdivision pharmacology
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Pyrimidines
General subdivision pharmacology
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Rats
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Rats, Inbred Lew
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element TYK2 Kinase
General subdivision antagonists & inhibitors
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Tuberculosis
General subdivision complications
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Ambler, Catherine M
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Arnold, Eric
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Banker, Mary Ellen
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Brown, Matthew F
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Chrencik, Jill
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Clark, James D
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Dowty, Martin E
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Efremov, Ivan V
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Flick, Andrew
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Gerstenberger, Brian S
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Gopalsamy, Ariamala
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Hayward, Matthew M
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Hegen, Martin
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Hollingshead, Brett D
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Jussif, Jason
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Knafels, John D
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Limburg, David C
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lin, David
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lin, Tsung H
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Pierce, Betsy S
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Saiah, Eddine
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Sharma, Raman
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Symanowicz, Peter T
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Telliez, Jean-Baptiste
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Trujillo, John I
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Vajdos, Felix F
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Vincent, Fabien
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Wan, Zhao-Kui
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Xing, Li
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Yang, Xiaojing
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Yang, Xin
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Zhang, Liying
773 0# - HOST ITEM ENTRY
Title Journal of medicinal chemistry
Related parts vol. 61
-- no. 19
-- p. 8597-8612
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://doi.org/10.1021/acs.jmedchem.8b00917">https://doi.org/10.1021/acs.jmedchem.8b00917</a>
Public note Available from publisher's website

No items available.