The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration. (Record no. 28043933)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02634 a2200769 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250517200459.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201904s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/acs.jmedchem.7b01731 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Adams, Christopher M |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20190415 |
| 245 00 - TITLE STATEMENT | |
| Title | The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | 02 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1622-1635 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article; Research Support, Non-U.S. Gov't |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Administration, Topical |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Choroidal Neovascularization |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Discovery |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Indoles |
| General subdivision | administration & dosage |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Ophthalmic Solutions |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Protein Kinase Inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyrazoles |
| General subdivision | administration & dosage |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyrimidines |
| General subdivision | administration & dosage |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rabbits |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rodentia |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Vascular Endothelial Growth Factor Receptor-2 |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Wet Macular Degeneration |
| General subdivision | drug therapy |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Anderson, Karen |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Artman, Gerald |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bizec, Jean-Claude |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cepeda, Rosemarie |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Elliott, Jason |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fassbender, Elizabeth |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ghosh, Malay |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanks, Shawn |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hardegger, Leo A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hosagrahara, Vinayak P |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jaffee, Bruce |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jendza, Keith |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ji, Nan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Johnson, Leland |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lee, Wendy |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liu, Donglei |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liu, Fang |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Long, Debby |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ma, Fupeng |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mainolfi, Nello |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Meredith, Erik L |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Miranda, Karl |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Peng, Yao |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Poor, Stephen |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Powers, James |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Qiu, Yubin |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rao, Chang |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shen, Siyuan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sivak, Jeremy M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Solovay, Catherine |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tarsa, Peter |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Woolfenden, Amber |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhang, Chun |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhang, Yiqin |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 61 |
| -- | no. 4 |
| -- | p. 1622-1635 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/acs.jmedchem.7b01731">https://doi.org/10.1021/acs.jmedchem.7b01731</a> |
| Public note | Available from publisher's website |
No items available.