Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. (Record no. 27463298)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02691 a2200817 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250517170446.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201710s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1546-170X |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1038/nm.4379 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Zhang, Pingzhao |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20171002 |
| 245 00 - TITLE STATEMENT | |
| Title | Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Nature medicine |
| Date of publication, distribution, etc. | Sep 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1055-1062 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Azepines |
| General subdivision | pharmacology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Blotting, Western |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell Cycle Proteins |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell Line, Tumor |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell Proliferation |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell Survival |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Resistance, Neoplasm |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Gene Expression Profiling |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Immunoprecipitation |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Male |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mechanistic Target of Rapamycin Complex 1 |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Molecular Targeted Therapy |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Multiprotein Complexes |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mutation |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Nuclear Proteins |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Prostatic Neoplasms |
| General subdivision | drug therapy |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Proteasome Endopeptidase Complex |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Protein Serine-Threonine Kinases |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Proto-Oncogene Proteins c-akt |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | RNA-Binding Proteins |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Repressor Proteins |
| General subdivision | genetics |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Reverse Transcriptase Polymerase Chain Reaction |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | TOR Serine-Threonine Kinases |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Transcription Factors |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Triazoles |
| General subdivision | pharmacology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | rac1 GTP-Binding Protein |
| General subdivision | genetics |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, Dejie |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhao, Yu |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ren, Shancheng |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gao, Kun |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ye, Zhenqing |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, Shangqian |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pan, Chun-Wu |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhu, Yasheng |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yan, Yuqian |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yang, Yinhui |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wu, Di |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | He, Yundong |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhang, Jun |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lu, Daru |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liu, Xiuping |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yu, Long |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhao, Shimin |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Li, Yao |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lin, Dong |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, Yuzhuo |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, Liguo |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, Yu |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sun, Yinghao |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, Chenji |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Huang, Haojie |
| 773 0# - HOST ITEM ENTRY | |
| Title | Nature medicine |
| Related parts | vol. 23 |
| -- | no. 9 |
| -- | p. 1055-1062 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1038/nm.4379">https://doi.org/10.1038/nm.4379</a> |
| Public note | Available from publisher's website |
No items available.