Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis. (Record no. 27085692)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02267 a2200649 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250517150910.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201707s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/acs.jmedchem.7b00032 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Desroy, Nicolas |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20170711 |
| 245 00 - TITLE STATEMENT | |
| Title | Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | 05 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 3580-3590 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Idiopathic Pulmonary Fibrosis |
| General subdivision | drug therapy |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Imidazoles |
| General subdivision | pharmacology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice, Knockout |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Phosphoric Diester Hydrolases |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyrimidines |
| General subdivision | pharmacology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Housseman, Christopher |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bock, Xavier |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Joncour, Agnès |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bienvenu, Natacha |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cherel, Laëtitia |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Labeguere, Virginie |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rondet, Emilie |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Peixoto, Christophe |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Grassot, Jean-Marie |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Picolet, Olivier |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Annoot, Denis |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Triballeau, Nicolas |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Monjardet, Alain |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wakselman, Emanuelle |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Roncoroni, Veronique |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Le Tallec, Sandrine |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Blanque, Roland |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cottereaux, Celine |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Vandervoort, Nele |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Christophe, Thierry |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mollat, Patrick |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lamers, Marieke |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Auberval, Marielle |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hrvacic, Boska |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ralic, Jovica |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Oste, Line |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | van der Aar, Ellen |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Brys, Reginald |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heckmann, Bertrand |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 60 |
| -- | no. 9 |
| -- | p. 3580-3590 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/acs.jmedchem.7b00032">https://doi.org/10.1021/acs.jmedchem.7b00032</a> |
| Public note | Available from publisher's website |
No items available.