Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity. (Record no. 26921619)

MARC details
000 -LEADER
fixed length control field 02640 a2200853 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250517141746.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 201704s 0 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1520-4804
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.1021/acs.jmedchem.7b00045
Source of number or code doi
040 ## - CATALOGING SOURCE
Original cataloging agency NLM
Language of cataloging eng
Transcribing agency NLM
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Scott, Jack D
264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Date of production, publication, distribution, manufacture, or copyright notice 20170424
245 00 - TITLE STATEMENT
Title Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.
Medium [electronic resource]
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Journal of medicinal chemistry
Date of publication, distribution, etc. 04 2017
300 ## - PHYSICAL DESCRIPTION
Extent 2983-2992 p.
Other physical details digital
500 ## - GENERAL NOTE
General note Publication Type: Journal Article
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Animals
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Brain
General subdivision metabolism
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Enzyme Inhibitors
General subdivision administration & dosage
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Indazoles
General subdivision administration & dosage
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
General subdivision antagonists & inhibitors
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Male
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Molecular Docking Simulation
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Parkinson Disease
General subdivision drug therapy
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Rats
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Rats, Wistar
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name DeMong, Duane E
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Greshock, Thomas J
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Basu, Kallol
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Dai, Xing
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Harris, Joel
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Hruza, Alan
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Li, Sarah W
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lin, Sue-Ing
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Liu, Hong
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Macala, Megan K
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Hu, Zhiyong
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Mei, Hong
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Zhang, Honglu
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Walsh, Paul
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Poirier, Marc
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Shi, Zhi-Cai
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Xiao, Li
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Agnihotri, Gautam
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Baptista, Marco A S
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Columbus, John
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Fell, Matthew J
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Hyde, Lynn A
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Kuvelkar, Reshma
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lin, Yinghui
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Mirescu, Christian
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Morrow, John A
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Yin, Zhizhang
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Zhang, Xiaoping
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Zhou, Xiaoping
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Chang, Ronald K
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Embrey, Mark W
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Sanders, John M
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Tiscia, Heather E
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Drolet, Robert E
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Kern, Jonathan T
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Sur, Sylvie M
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Renger, John J
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Bilodeau, Mark T
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Kennedy, Matthew E
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Parker, Eric M
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Stamford, Andrew W
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Nargund, Ravi
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name McCauley, John A
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Miller, Michael W
773 0# - HOST ITEM ENTRY
Title Journal of medicinal chemistry
Related parts vol. 60
-- no. 7
-- p. 2983-2992
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://doi.org/10.1021/acs.jmedchem.7b00045">https://doi.org/10.1021/acs.jmedchem.7b00045</a>
Public note Available from publisher's website

No items available.